Films
| Year | Title | Role |
|---|---|---|
| 2005 | The Ring Two | Young Evelyn Borden (née Osorio) |
| 2005 | Checking Out | Lisa Apple |
| 2005 | Sky High | Gwen Grayson / Royal Pain / Sue "Tenny" Tennyson |
| 2006 | Final Destination 3 | Wendy Christensen |
| 2006 | Bobby | Susan Taylor |
| 2006 | Black Christmas | Heather Fitzgerald |
| 2006 | Factory Girl | Ingrid Superstar |
| 2007 | Death Proof | Lee Montgomery |
| 2007 | Live Free or Die Hard | Lucy Gennero-McClane |
| 2008 | Make It Happen | Lauryn Kirk |
| 2010 | Scott Pilgrim vs. the World | Ramona Flowers |
| 2011 | The Thing | Dr. Kate Lloyd |
| 2012 | Smashed | Kate Hannah |
| 2012 | Abraham Lincoln: Vampire Hunter | Mary Todd Lincoln |
| 2013 | A Glimpse Inside the Mind of Charles Swan III | Kate |
| 2013 | The Spectacular Now | Holly Keely |
| 2013 | A.C.O.D. | Lauren Stinger |
| 2013 | A Good Day to Die Hard | Lucy Gennero-McClane |
| 2014 | Faults | Claire |
| 2014 | Alex of Venice | Alex Vedder |
| 2014 | Kill the Messenger | Anna Simons |
| 2014 | Showing Up | Herself |
| 2016 | Swiss Army Man | Sarah Johnson |
| 2016 | The Hollars | Gwen |
| 2016 | 10 Cloverfield Lane | Michelle |
| 2018 | All About Nina | Nina Geld |
| 2019 | Gemini Man | Danielle "Danny" Zakarewski |
| 2019 | The Parts You Lose | Gail |
| 2020 | Birds of Prey | Helena Bertinelli / The Huntress |
| 2021 | Kate | Kate |
Short films
| Year | Title | Role |
|---|---|---|
| 2008 | Stop/Eject | Elizabeth |
| 2011 | Cost of Living | The Computer (voice) |
| 2011 | Magnificat | Lynn |
| 2012 | Casque | Girl |
| 2013 | The Cub | |
| 2016 | So It Goes | Samantha |
| 2019 | The Cloverfield Files | Michelle |
Television
| Year | Title | Role |
|---|---|---|
| 1997 | Touched by an Angel | Kristy |
| 1998 | Promised Land | Chloe |
| 1999–2000 | Passions | Jessica Bennett |
| 1999 | The Long Road Home | Annie Jacobs |
| 2000 | Father Can't Cope | Tara |
| 2001–2002 | Wolf Lake | Sophia Donner |
| 2003 | Then Came Jones | Rina |
| 2004 | Tru Calling | Bridget Elkins |
| 2004 | Monster Island | Madison |
| 2012 | The Beauty Inside | Leah |
| 2015 | Exposed | Anna Loach |
| 2015 | Quarry | Joni |
| 2015 | The Returned | Rowan Blackshaw |
| 2015 | Comedy Bang! Bang! | Herself |
| 2016 | Brad Neely's Harg Nallin Sclopio Peepio | Guest Star (voice) |
| 2016 | BrainDead | Laurel Healy |
| 2016–2017 | Mercy Street | Mary Phinney |
| 2017 | Fargo | Nikki Swango |
| 2017 | Danger & Eggs | Trix Blixon (voice) |
| 2019 | Love, Death & Robots | Gail |